MYO15A mutations are known to be responsible for DFNB3 (Wang et al., 1998) and further phenotypic study indicated that there are two types of hearing impairment phenotypes: (1) prelingual onset and severe or profound hearing loss or (2) a milder phenotype with postlingual onset and progressive hearing loss (Miyagawa et al. 2015a). This evidence concerns the gene MYO15A and Hearing impairment.