The concept of opened and closed full‐length pseudokinase conformations has been demonstrated for STRADα.54 LKB1 is a tumor suppressor and inactivating mutations cause the inherited Peutz–Jeghers cancer syndrome.55 LKB1 is the key upstream activator of multifaceted AMP‐activated protein kinase (AMPK) activities. This evidence concerns the gene STK11 and neoplasm.