Given the role of the KATP channel in insulin secretion, it is not unexpected that variants in KCNJ11, encoding the four pore‐forming inwardly rectifying Kir6.2 subunits, and ABCC8, encoding the four sulphonylurea receptor 1 (SUR1) subunits of the channel, can cause hypo‐ or hyperglycemia (Babenko et al., 2006; Gloyn, Pearson, et al., 2004; Thomas et al., 1995; Thomas, Ye, & Lightner, 1996). This evidence concerns the gene INS and Hyperglycemia.