F8 and hemophilia: According to the guidelines for hemostasis strategy for patients with hemophilia without inhibitor published by the Japanese Society on Thrombosis and Hemostasis [2], we planned the following perioperative FVIII replacement protocol: bolus injection of 3000 IU (50 IU/kg) FVIII followed by continuous intravenous infusion at a rate of 240 IU/h (4 IU/kg/h) for 24 h, bolus injection of 6000 IU/day for 5 days after surgery, and bolus injection of 3000 IU/day for the next 3 days.