F8 and hyperinsulinemic hypoglycemia, familial, 4: The results for TEG before administration of FVIII concentrate showed prolonged R values for CK and CKH (10.8 and 9.2 min, respectively) and normal R value for CRT (0.6 min) (Fig. 2a), which indicated retardation of thrombin generation via intrinsic pathway due to FVIII deficiency.