The hepatic expression of other kinases (Hk2, Hk4, and Khk) and Slc2a2 was not affected by the fructose content of the diet in females, or were glycolysis‐related enzymes or Mttp1. DNL‐related enzyme expression was not significantly altered, except for a higher Scd1 expression in HF‐F females compared with HF‐G females. Here, GCK is linked to hydrops fetalis.