They are used as insulin sensitizers to control hyperglycemia in type 2 diabetes (Tontonoz & Spiegelman, 2008) and to protect kidneys from diabetic and nondiabetic injuries by reducing microalbuminuria (Bakris et al., 2006; Sarafidis, Stafylas, Georgianos, Saratzis, & Lasaridis, 2010; Sugawara et al., 2012). Here, INS is linked to Hyperglycemia.