It was therefore not surprising to detect higher concentrations of selective cytokines (e.g., IL‐1β, IL‐2, IL‐4, EGF, and HGF) in the GCF of the SCN patients, compared to the controls, indicating an inherent perturbation of inflammatory networks within the oral milieu of these patients. The gene discussed is HGF; the disease is severe congenital neutropenia.