In 1990, a therapy with granulocyte colony‐stimulating factor (G‐CSF), found to restore blood neutrophil counts in most of the SCN patients to physiological levels, was introduced.[4] Although the G‐CSF therapy has led to increased life expectancy and quality of life in the affected individuals, they still remain prone to infections, and the SCN is associated with poor periodontal health.[5, 6, 7]. Here, CSF3 is linked to infection.