Cheng et al. who found that an intravenous preptin infusion administered to rats induced a reduction in the plasma glucose level that was related to insulin secretion during glucose loading.103 They also reported that the effect of preptin on insulin secretion by a mouse insulinoma cell line was similar to that of glibenclamide, which stimulates insulin secretion by inhibiting ATP‐responsive potassium channels and subsequent calcium influx in pancreatic beta cells. Here, INS is linked to pancreatic insulinoma.