Further research into the latter process revealed that mature IGF‐II had no effect on this.120 Based on the above, it can be argued that it is worthwhile to conduct more research into the possible therapeutic values of pro‐IGF‐II variants and preptin (or derivatives thereof) in the treatment of type 2 diabetes, osteoporosis and complicated fractures, and muscle regeneration, respectively. Here, IGF2 is linked to osteoporosis.