In subjects with diabetes duration of less than 5 years, fasting insulin decreased from 11.1 ± 4.1 to 6.3 ± 2.1 mcIU/ml, and HOMA-IR improved significantly from 3.39 ± 1.2 to 2.08 ± 0.8 after KRG treatment (p = 0.044 and p = 0.046, respectively). This evidence concerns the gene INS and diabetes mellitus.