The immune responses of TB vaccines in guinea pigs have been studied by several methods such as antibody blocking, flow cytometry, bioassays, and microarray [12, 77], demonstrating that M. tuberculosis infection could initially activate responding T cells (mostly CD4 cells), which dramatically decreased in number 30 days after the infection and were gradually replaced by steadily increasing B cells and granulocytes [12]. This evidence concerns the gene CD4 and tuberculosis.