Recently, some new humanized mouse models have been developed to identify potential TB or other vaccine candidates, including humanized NOD/shi-scid/γcnull (NOG) mice [198], NOD/SCID/γcnull (NSG) mice engrafted with human fetal liver and thymus tissues, and CD34+cells [199], DRAG mice (NSG mice transgenic for human DR4, RRID:IMSR_JAX:017914) [200], HSC-engrafted NSG mice [201], HLA-A2 transgenic NSG-BLT mice [201], and NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice [202]. The gene discussed is CTSG; the disease is tuberculosis.