Subgroup analysis showed that T2DM patients with detectable concentrations of urinary IL-8 (WIL8) had a different urinary bacterial profile from those with no detectable concentrations of urinary IL-8 (NIL8); indeed, the WIL8 group had notable elevations and reductions in several bacterial genera and species compared to the NIL8 group. This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.