CEACAM5 and neoplasm: The LPFS was significantly shortened in patients with high risk (3 to 5) of clinical risk score (CRS, including the primary tumor node state, CEA level, size and number of liver metastases, and synchronous or metachronous metastases) compared with those with low risk (0 to 2)(40 months vs. 12 months, p < 0.001).