BRCA1 and breast cancer: Variants c.66_67delAG and c.5266dupC of BRCA1 have been used for breast cancer prevention among Jewish women.13 In Africa, founder mutations have been reported in Yoruba population from Nigeria (c.303T>G;(p.Tyr101Ter)) in a series of four families,13 in Afrikaners from South Africa (c.2641G>T (p.Glu881Ter))14 in five families, and in Morocco (c.5309G>T; (p.Gly1770Val)) in five families.11 The founding effect of the variant c.815_824dup10 was reported first in five nonrelated families from US20 and the mutation was supposed to be of West African origin.