TP53 and glioblastoma: A problem of glioblastoma is its presentation as a heterogeneity of altered genetic pathways, evidenced by The Cancer Genome Atlas Research Network’s study classification based on gene expression profiles.73 Glioblastoma can be genetically typed66; Classical glioblastoma, with its highest survival rates, harbours no TP53 mutations, but high rates of EGFR mutations.