Novel and/or de novo germ-line mutations of the adenomatous polyposis coli (APC) occur in up to 25% of FAP patients when untreated, the incidence of colorectal cancer is high.11,104–106 The most frequent germ-line APC mutations occur on codons 1061 and 1309. This evidence concerns the gene APC and Familial adenomatous polyposis.