Notable examples of known cancer syndromes and the genes involved include X-linked recessive Simpson Golabi Behmel syndrome (caused by GPC3 mutations), X-linked lymphoproliferative disease (caused by SH2D1A abnormalities), autosomal recessive ataxia telangiectasia (ATM mutations), Bloom syndrome (BLM mutations), Fanconi anemiam (FANC family), MUTYH-associated polyposis (MUTYH), Nijmegen breakage syndrome (NBN), Rothmund-Thomson syndrome (RECQL4) and Werners syndrome (WRN) (reviewed in the ref. 43). Here, GPC3 is linked to Werner syndrome.