BRCA1 and hereditary cancer: This highlighted the importance of BRCA1/2 mutations for the high prevalence of ovarian cancer observed across the Arab world.9 This was further supported by Siraj et al. who characterised the spectrum of BRCA1/2 mutations regarding prevalence and founder effects in Arab regions to advance genetic counselling.39 Despite clear progress in our understanding of ethnic-specific hereditary cancer, problems still remain that are specific to the Arab region.