Specific mitochondrial protein-coding genes [26] but also genes involved in collagen and cholesterol synthesis (Patatin-like phospholipase domain-containing protein 3 - (PNPLA3) [27], insulin signaling (Insulin Receptor Substrate 1 - IRS1), and innate immunity activation (MERTK) inconstantly and heterogeneously associate with NASH. The gene discussed is IRS1; the disease is metabolic dysfunction-associated steatohepatitis.