Meanwhile, The relationship between B7 family member expression and patient clinicopathological features has been investigated in HCC, in which B7-H1/H4 were associated with serosa invasion, lymph node metastasis, and tumor stage, while B7-H3 was associated with clinical stage and distant metastasis 13,35, and B7-H6 was significantly associated with a higher differentiation 22. The gene discussed is CD276; the disease is hepatocellular carcinoma.