However, whether Akt activation and Nrf2 upregulation plays important roles in the effects of FF treatment on DN, which Akt isoforms up-regulated by FF provides protection on DN, whether its isoform is the only target in the process of FF protection on DN by mediating Nrf2 up-regulation induced by FGF21. The gene discussed is NFE2L2; the disease is liver dysplastic nodule.