Considering that FF protection from T1D-induced nephropathy relies on FGF21-dependent activation of Nrf2 function and the Akt/GSK-3β/Fyn signaling pathway 19, we evaluated the impact of silencing Akt2 expression on FF-induced Nrf2 activity in HK-2 cells maintained in a HG or normal glucose environment. This evidence concerns the gene FGF21 and kidney disorder.