Although protein-coding regions span only about 1% of the genome, 15 out of 50 (30%) of the most frequently mutated sites were well-studied hotspots in cancer genes (KRAS, BRAF, PIK3CA, TP53 and IDH1) (Fig. 1a, Extended Data Fig. 1b), along with the two canonical TERT promoter hotspots6,7. Here, TERT is linked to cancer.