TERT and cancer: Overall, this approach predicted more than 1,475 driver mutations (95% confidence interval 1,410–1,687; 1,069 SNVs and 406 indels) in the protein-coding sequences of these cancer genes (Fig. 4d), compared to only 96 (95% confidence interval 30–190) estimated driver mutations in promoters (73 attributed to TERT), 22 (95% confidence interval 0–88) in 5′UTRs, and 68 (95% confidence interval 0–178) in 3′ UTRs.