These include well-known cancer-associated genes, such as CCND1 (25 tumors), CDK4 (25 tumors), MDM2 (23 tumors), SETDB1 (23 tumors), ERBB3 (11 tumors), ERBB2 (11 tumors), MYC (10 tumors) and MYCN (five tumors). The gene discussed is SETDB1; the disease is cancer.