Regulatory landscapes are an important part of human malignancies, and studies have shown that the ‘hijacking’ of enhancers can lead to overexpression of oncogenes (for example, growth factor independent 1 family oncogenes (GFI1 and GFI1B)) in medulloblastoma13 or proto-oncogene MECOM activation due to an inversion between TADs in acute myeloid leukemia cells, which facilitates tumor formation14. The gene discussed is GFI1; the disease is neoplasm.