In a second esophageal tumor sample, SA528899, an L1 element integrated into chromosome 9 promoted an 8.6-Mb clonal deletion that encompasses the 9p22.1–9p21.1 region that removes one copy of the same tumor-suppressor gene, CDKN2A (Fig. 5d). Here, CDKN2A is linked to neoplasm of esophagus.