Of these CLC genes, 20% are divergent to a CGC gene, compared with 5% for non-CLC genes (p-value = 0.018, Fisher’s exact test) (Fig. 5d), and several are divergent to protein-coding genes that have also been linked or defined to be involved in cancer, despite not being classified as CGCs (Supplementary Data 2). This evidence concerns the gene CLC and cancer.