CD8A and infection: CD8+ cDC1s are the main source of IL-12 within a few hours after infection,26,58 and shortly thereafter, interferon-γ (IFN-γ)-primed CD11b+ cDC2s and PDCA1+ pDCs additionally contribute to IL-12 production.34 Therefore, we explored the impact of OTUB1 on DC-mediated IL-12 production during T. gondii infection.