Since OTUB1 has been reported to interact with molecules critical for activation of the immune system and DCs are key immune cells that protect the host from various infectious diseases, including toxoplasmosis,25,26 but also contribute to immunopathology in sepsis,21,27–29 we asked whether DC-specific OTUB1 is regulated during murine toxoplasmosis and LPS-induced sepsis. Here, OTUB1 is linked to Sepsis.