For example, as previously indicated, the shared genetic variant at IL12RB2 influenced IL12RB2 gene expression levels; however, whereas the minor allele (which conferred risk to SSc in our study) correlated with an increased gene expression in whole blood, the major allele (which conferred risk to CD) had the same effect (increased IL12RB2 expression) in fibroblasts, according to GTEx data. Here, IL12RB2 is linked to systemic sclerosis.