Additionally, KIHC, PAAD, PRAD, and STAD cancers were found to be associated with a number of NR gene pairs containing at least one NR class III genes (estrogen receptor-like NRs, e.g. AR, ESR1, ESRRA, ESRRB, ESRRG, NR3C1, NR3C2, and PGR), whereas THYMs were strongly associated with NR class I genes (thyroid hormone receptor-like NRs, e.g. PPAR, RAR, ROR genes). The gene discussed is ESR1; the disease is cancer.