Examination of mRNA expression in all 21 cancer types revealed positive correlation between three NR gene clusters, namely 1) NR4A1, NR4A2, NR4A3 (NR class IV), 2) AR, ESR1, ESRRG, NR2E3, NR3C2, PGR, RORC, THRB (NR class I/II/III), and 3) HNF4A, HNF4G, NR0B2, NR1H3, NR1H4, NR1I2, NR5A2, PPARA, PPARG (NR class 0/I/II/V; Fig. 4A). The gene discussed is NR1H4; the disease is cancer.