In total, five NRs (10%; ESR2, ESRRB, NR2E3, NR6A1, RORB) were not expressed in any tissue, whereas 22 NRs (46%; AR, ESR1, ESRRG, HNF4A, HNF4G, NR0B1, NR0B2, NR1H4, NR1I2, NR1I3, NR2E1, NR2F1, NR3C2, NR4A3, NR5A1, NR5A2, PGR, PPARG, RARB, RORC, RXRG, THRB) showed restricted expression patterns in specific ‘Pan-Cancer’ organ systems, e.g. gynecologic, endocrine, urologic, central nervous system, gastrointestinal, and thoracic (Supplementary Table 1). This evidence concerns the gene ESRRB and cancer.