Intriguingly, gene expression analysis showed that approximately 20% of NRs (ESRRA, NR1D2, NR1H2, NR2C1, NR2C2, NR4A1, PPARD, RARA, RXRA, RXRB) were ubiquitously expressed in all 33 pan-cancers. This evidence concerns the gene ESRRA and cancer.