THRB and invasive breast carcinoma: Although a number of ‘Pan-Cancer’ diseases (BRCA/CESC and PAAD/READ) and NRs (NR class I: THRA/THRB, RORA/PPARA, RARB/RORB, NR1H3/NR1H4/PPARD, and RARA/NR1H2/NR1I3; NR class II: HNF2A/HNF4G, NR2F1/RXRA/RXRG, and NR2E3/NR2C2/RXRB; NR class IV: NR4A1/NR4A2) belonging to the same groups clustered together, hierarchical clustering of the log-rank test p-values showed no clear correlation between prognostic potential and pan-organ system or NR class (Fig. 5A).