In consequence, several tyrosine kinase inhibitors targeting FLT3 have been developped, and recently, an improvement in overall survival was shown for the first time through a randomized phase-3 controlled trial that combined first-generation multi-targeted type II FLT3-TKI midostaurin (PKC412) with standard chemotherapy in both newly diagnosed FLT3-ITD and FLT3-TKD AML, and which led to the approval of midostaurin in this indication in 2017 and its common use since then4. Here, FLT3 is linked to acute myeloid leukemia.