BCs with high mutation rates enriched cell proliferation and cell cycle related gene sets; E2F targets (Normalized enrichment score (NES) = 2.04, p < 0.001), mTORc1 signaling (NES = 2.01, p < 0.01), MYC targets (NES = 1.84, p = 0.01), and G2M checkpoint (NES = 2.00, p < 0.01), which suggest aggressive cancer phenotypes (Fig. 5A). The gene discussed is MYC; the disease is cancer.