HAVCR2 and neoplasm: While performing expression clustering and time course analysis of the TCE network genes, we noticed that markers of ‘reversible exhaustion’ (e.g. high CXCR5 in LCMV infections, high TCF-1 in tumor-infiltrating lymphocytes, accompanied with low levels of KLRG1 and TIM-3) overlap with and include pro-memory genes, and exclude genes associated with effector function and ‘irreversible exhaustion’ (Supplementary Fig. S23).