TP53 and cancer: In addition, the overwhelming majority of the PID-N genes were distinct from PID-C genes (Supplementary Fig. 4) with only five genes in common: CTNNB1, DDX3X, SF3B1, TGFBR2, and TP53. While this suggests that coding and non-coding driver mutations occur in largely distinct sets of cancer genes, we show below that both types of mutations affect genes underlying many of the same hallmark cancer processes.