In addition, the overwhelming majority of the PID-N genes were distinct from PID-C genes (Supplementary Fig. 4) with only five genes in common: CTNNB1, DDX3X, SF3B1, TGFBR2, and TP53. While this suggests that coding and non-coding driver mutations occur in largely distinct sets of cancer genes, we show below that both types of mutations affect genes underlying many of the same hallmark cancer processes. This evidence concerns the gene TGFBR2 and cancer.