SMAD3 and cancer: Additional known cancer genes included the oncogene MYC with 13 patients with 3′UTR mutations (driver P-value PUTR3 = 4.8 × 10−4), the transcription factor SMAD3 of the TGF-β pathway with 14 patients with protein-coding mutations (PCDS = 4.0 × 10−4) and the growth inhibitory tumor suppressor gene TSC1 with 23 patients with protein-coding mutations (PCDS = 1.4 × 10−4) as well as candidate cancer genes such as IQGAP1 with ten patients with promoter mutations (Ppromoter = 8.2 × 10−4) that encodes a signaling protein involved in cell motility and morphology.