A recent study by Weischenfeldt et al.9, utilizing SNP arrays to estimate SV breakpoints occurring within TADs (which confine physical and regulatory interactions between enhancers and their target promoters), uncovered 18 genes (including TERT and IRS4) in pan-cancer analyses and 98 genes (including IGF2) in cancer type-specific analyses with overexpression associated with rearrangements involving nearby or surrounding TADs. The gene discussed is IRS4; the disease is cancer.