As primary immunodeficiency-related genes were correlated with TfR1 low-expressed cells, we detected fold changes of PD-L1, CXCL9, and CXCL10 mRNA levels in TfR1-knockout cells, which were enhanced after IFN-γ treatment (Fig. 5e). The gene discussed is CXCL10; the disease is inborn error of immunity.