Analysis of tumor–genome features (GSEA on KEGG and hallmark gene sets) based on RNA-seq and TCGA datasets revealed that the upregulated genes were enriched in signaling pathways regulating the pluripotency of stem cells, cytokine–cytokine receptor interaction, myogenesis, and primary immunodeficiency, which was significantly enriched in TFRC low-expression cells or groups. Here, TFRC is linked to inborn error of immunity.