Using the multivariate Cox’s model, TfR1 was shown to be a novel independent prognostic factor of 5-year OS (HR = 0.450; 95% CI: 0.286–0.708; P = 0.001), compared with other independent prognostic factors including lymph node metastasis (P < 0.001), depth of invasion (P = 0.016), distant metastasis (P < 0.001), and tumor size (P = 0.017). Here, TFRC is linked to neoplasm.