TFRC and gastric cancer: The level of TfR1 mRNA in normal and GC specimens was analyzed by the Gene Expression Omnibus (GEO) database (GES13861 and GES63089), which indicated that TfR1 mRNA level was significantly higher in GC tissues compared with adjacent noncancerous mucosa tissues (P < 0.0001 and P < 0.0001, respectively) (Fig. 1c).