Based on our prior studies on how the early cell death checkpoint in the TNFR1 pathway is regulated, where we found that CYLD switches RIPK1 to become a death-signaling molecule25,46,47, we considered the possibility that the tumor suppressive function of CYLD might be due to its ability to switch RIPK1 to a death-signaling mode. Here, TNFRSF1A is linked to neoplasm.