We were prompted to examine the role of CYLD phosphorylation in ATLL lymphomagenesis based on reports that NEMO/IKKβ and IKKε can phosphorylate a cluster of serines between residues 418 and 444 of CYLD resulting in the inhibition of CYLD’s catalytic activity48,49. The gene discussed is IKBKB; the disease is adult T-cell leukemia/lymphoma.