For example, in pancreatic ductal adenocarcinoma (Panc-AdenoCA; N = 232), the addition of functional adjustment to the algorithm resulted in a gain of three additional drivers (ACVR1B, RBM10 and ZFP36L2) and the loss of one likely false-positive genes (FAU) (Fig. 2a). The gene discussed is ZFP36L2; the disease is pancreatic ductal adenocarcinoma.