H2AC6 and cancer: DriverPower identified four histone genes as driver candidates in the pan-cancer cohort, two of which were absent from CGC or PCAWG-consensus: the 5′-UTR of HIST1H2AC and HIST1H2BD. Previous studies have shown that the protein levels of the replication-dependent histone H2A variant HIST1H2AC (encoding histone H2A type 1-C) is decreased in chronic lymphocytic leukaemia patients and bladder cancer cells45,46, and the siRNA knockdown of HIST1H2AC increases cell proliferation and promote oncogenesis46.