The tumor types with the highest prevalence of ATRX/DAXXtrunc mutations were liposarcomas (32%), adult lower grade gliomas (28%), pancreatic endocrine tumors (23%), and osteosarcoma (17%; Fig. 1b and Supplementary Fig. 3a, b), all of which have previously been associated with ALT12,31. Here, ATRX is linked to central nervous system cancer.