To propose such a strategy, we investigated the relationship between the infiltrative nature of GBM tumor cells and the mechanism of interaction between two main GBM cellular subtypes: a cellular subtype harboring mutation in epidermal growth factor receptor (EGFR), EGFRvIII, and a subtype overexpressing wild type EGFR (EGFRwt). This evidence concerns the gene EGFR and glioblastoma.