Furthermore, in glioblastoma, kindlin-3 contributed to resistance to telozolomide and cell proliferation through Wnt signaling (Lu et al, 2017), whereas overexpression of kindlin-3 in melanoma cells led to imbalanced Rho GTP-ase activation and inhibition of cell migration (Feng et al, 2017). This evidence concerns the gene FERMT3 and melanoma.