Kindlin-3 overexpression in a BC cell line increased primary tumor growth and lung metastasis and mechanistically, kindlin-3–overexpressing cells displayed a marked increase in VEGF secretion, which was dependent upon enhanced expression of the Twist transcription factor (Sossey-Alaoui et al, 2014) and enhanced β1 integrin activation. The gene discussed is FERMT3; the disease is neoplasm.