TLR2 and Anorexia: Another study in mice has demonstrated that TLR2 activation by i.c.v. injection of a synthetic TLR2 agonist triggered hypothalamic inflammation by the activation of the microglial NF-κB signal pathway in the ARC, which resulted in an increased activity of POMC neurons, increased α-MSH fibres in the hypothalamic PVN, and anorexia (Jin et al., 2016).