BRAF and melanoma: The TCGA consortium has previously classified melanomas in four molecular subtypes based on their genomic profiles (BRAF, RAS, NF1, and triple wild-type), three transcriptional subclasses based on their gene expression signatures (Immune, Keratin, MITF-low) and four methylation clusters based on their methylation patterns (CpG island-methylated, hyper-methylated, hypo-methylated and normal-like) [36].