PVT1 and neoplasm: Based on the strategy of competitive endogenous RNA (ceRNA) networks [15], overexpression of PVT1 correlates with a poor prognosis [16] or a fast tumor progression [17] in esophageal cancer patients or in ESCC [18] In this study, PVT1 was indicated as an EAC-specific lncRNA since it does not belong to the intersection set between lncRNAs for these two subtypes.