The pathways enriched by PPI targets of HB disease mainly included the following 23 pathways: PI3K-Akt, TNF, T cell receptor, Epstein-Barr virus infection, Toll-like receptor signaling, JAK/STAT, natural killer T cell-mediated cytotoxicity, NF-κB, RIG-I-like receptor signaling, VEGF, antigen processing and presentation, MAPK, FoxO, Ras, HIF-1, primary immunodeficiency, NOD-like receptor signaling, neurotrophin, adipocytokine, sphingolipid signaling, hematopoietic cell lineages, B cell receptor signaling, and chemokine signaling. This evidence concerns the gene BDNF and Epstein-Barr virus infection.