STAT3 and colorectal carcinoma: Although the exact role of the STAT3 pathway has not yet been elucidated in HFD-accelerated CRC, previous studies reported that HFD exacerbated the extent of cancer progression via STAT3 signaling in various diseases, suggesting that the STAT3 signaling pathway is one of the underlying molecular mechanisms involved in HFD-propelled tumorigenesis [14,15].