As expected, diabetes reduced protein levels of ZO-1 in diabetic ADAM17flox mice compared to control normoglycemic mice (p < 0.01); however, the knockdown of ADAM17 helped preserve the levels of ZO-1 in diabetic ADAM17Cre-flox mice (p < 0.05 diabetic ADAM17flox vs. diabetic ADAM17Cre-flox mice; Figure 3D). Here, ADAM17 is linked to diabetes mellitus.