ADAM17 and diabetes mellitus: As expected, diabetes-induced expression of the leukocyte adhesion molecule ICAM-1 in retinas of ADAM17flox mice (p < 0.001 vs. corresponding control; Figure 4C), but knockdown of vascular ADAM17 significantly reduced retinal ICAM-1 protein levels in diabetic ADAM17Cre-flox mice (p < 0.01 diabetic ADAM17flox vs. diabetic ADAM17Cre-flox mice; Figure 4C).