Other studies demonstrated that Müller cell swelling was mediated by VEGF and AQP4 [40], further demonstrating a link between VEGF and AQP4; (5) Bumetanide reductions in VEGF were associated with reductions in the severity of OIR, particularly hemorrhages, vascular tortuosity, and migration of retinal endothelial cells into the vitreous fluid, characteristics that are highly influenced by VEGF and AQP4. Here, AQP4 is linked to hemorrhage.