Studies show that exposure of AQP4 knockout mice to hypoxia results in reduced retinal neovascularization, demonstrating the key role of AQP4 in this process [39]; (2) Bumetanide appears to be a more potent and consistent inhibitor of ocular AQP4 than it is for AQP1, at least in the setting of neonatal IH. This evidence concerns the gene AQP4 and isolated hemihyperplasia.