The major findings of this study were that early postnatal bumetanide reduced the severity of OIR induced by neonatal IH likely due to suppression of AQP4 and that bumetanide shortened the caecal period, suggesting precocious retinal neural and visual cortex maturation, corneal development, and possible improved visual acuity. The gene discussed is AQP4; the disease is isolated hemihyperplasia.