Similarly to AML, B-ALL presents a wide variety of genetic anomalies that include aneuploidy, fusion proteins (e.g., Ets-leukemia virus 6 - Runt-related transcription factor 1 (ETV6-RUNX1); breakpoint cluster region - Abelson1 (BCR-ABL1); rearrangements in the MLL gene; aberrations in key genes of B-cell development (e.g., paired box 5 (PAX5) and Ikaros family zinc finger protein 1 (IKZF1)) or cell cycle-related genes (CDKN2A); Neuroblastoma-Ras (N-Ras) point mutations (e.g., G12D). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.