GFAP and mucopolysaccharidosis: The number of Glial fibrillary acidic protein (GFAP)-positive astrocytes and ILB4-positive microglia cells was augmented in all studied human MPS cortex tissues except for those of the non-neurological MPS II patient 902 (Figure 3A), suggesting that neuroinflammation previously reported in all mouse models was also heavily present in human patients.