However, a decrease of homovanillic acid (Z-score 2.95, rank 3) in P038.1 with dihydropteridine reductase deficiency and a decrease of 5-hydroxyindoleacetic acid (Z-score -1.64, rank 24) in P070.1 with DNAJC12 deficiency ensure that, in both these samples, DNAJC12 deficiency ranks second and dihydropteridine reductase deficiency ranks third. The gene discussed is DNAJC12; the disease is hyperinsulinemic hypoglycemia, familial, 4.