PPARGC1A and acute kidney injury: Tran M et al. demonstrated the reduction of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a major transcription factor for mitochondrial biogenesis, and its downstream genes in renal tubular cells during septic AKI, and importantly ablation of PGC-1α from renal tubule cells suppressed the renal recovery from AKI [30,31].