In order to assess the effect of nicotine treatment on mice bearing patient-derived pancreatic cancer xenograft, two sex-matched patient-derived xenografts from patients with PDAC were implanted onto the pancreas of 12 week old male and female NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice. The gene discussed is CTSG; the disease is pancreatic neoplasm.