Although the genetic or antibody depletion methods utilized in these studies also reduced adipose NKT cells, which can suppress insulin resistance during diet-induced obesity [104,105], adoptive transfer of CD49b+ splenic NK cells into the VAT of Ifng−/− mice was sufficient to exacerbate insulin resistance following high fat diet (HFD) administration [35]. Here, IFNG is linked to obesity due to melanocortin 4 receptor deficiency.